Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
| Phenotype | Phenotype.cls#treated_versus_cont_repos |
| Upregulated in class | treated |
| GeneSet | KEGG|HSA03030 |
| Enrichment Score (ES) | 0.8579755 |
| Normalized Enrichment Score (NES) | 1.6815622 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.016804567 |
| FWER p-Value | 0.377 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 4175 | MCM6 (minichromosome maintenance complex component 6) | 78 | 163.812 | 0.1052 | Yes | ||
| 2 | 5111 | PCNA (proliferating cell nuclear antigen) | 102 | 146.221 | 0.2014 | Yes | ||
| 3 | 6742 | SSBP1 (single-stranded DNA binding protein 1) | 121 | 130.924 | 0.2876 | Yes | ||
| 4 | 4176 | MCM7 (minichromosome maintenance complex component 7) | 145 | 121.439 | 0.3673 | Yes | ||
| 5 | 5983 | "RFC3 (replication factor C (activator 1) 3, 38kDa)" | 215 | 100.338 | 0.4307 | Yes | ||
| 6 | 4171 | MCM2 (minichromosome maintenance complex component 2) | 259 | 91.901 | 0.4898 | Yes | ||
| 7 | 246243 | RNASEH1 (ribonuclease H1) | 319 | 83.627 | 0.5425 | Yes | ||
| 8 | 2237 | FEN1 (flap structure-specific endonuclease 1) | 348 | 79.316 | 0.5939 | Yes | ||
| 9 | 54107 | "POLE3 (polymerase (DNA directed), epsilon 3 (p17 subunit))" | 422 | 69.681 | 0.6367 | Yes | ||
| 10 | 5557 | "PRIM1 (primase, DNA, polypeptide 1 (49kDa))" | 756 | 47.079 | 0.6516 | Yes | ||
| 11 | 4172 | MCM3 (minichromosome maintenance complex component 3) | 816 | 43.892 | 0.6779 | Yes | ||
| 12 | 5425 | "POLD2 (polymerase (DNA directed), delta 2, regulatory subunit 50kDa)" | 912 | 40.218 | 0.7000 | Yes | ||
| 13 | 4174 | MCM5 (minichromosome maintenance complex component 5) | 954 | 38.341 | 0.7235 | Yes | ||
| 14 | 10535 | "RNASEH2A (ribonuclease H2, subunit A)" | 1205 | 30.992 | 0.7318 | Yes | ||
| 15 | 56655 | "POLE4 (polymerase (DNA-directed), epsilon 4 (p12 subunit))" | 1257 | 29.945 | 0.7493 | Yes | ||
| 16 | 5982 | "RFC2 (replication factor C (activator 1) 2, 40kDa)" | 1288 | 29.303 | 0.7673 | Yes | ||
| 17 | 6119 | "RPA3 (replication protein A3, 14kDa)" | 1289 | 29.297 | 0.7868 | Yes | ||
| 18 | 23649 | "POLA2 (polymerase (DNA directed), alpha 2 (70kD subunit))" | 1598 | 23.976 | 0.7876 | Yes | ||
| 19 | 5985 | "RFC5 (replication factor C (activator 1) 5, 36.5kDa)" | 1617 | 23.676 | 0.8024 | Yes | ||
| 20 | 5424 | "POLD1 (polymerase (DNA directed), delta 1, catalytic subunit 125kDa)" | 1866 | 20.334 | 0.8037 | Yes | ||
| 21 | 4173 | MCM4 (minichromosome maintenance complex component 4) | 1938 | 19.630 | 0.8133 | Yes | ||
| 22 | 5558 | "PRIM2 (primase, DNA, polypeptide 2 (58kDa))" | 2031 | 18.485 | 0.8211 | Yes | ||
| 23 | 6118 | "RPA2 (replication protein A2, 32kDa)" | 2048 | 18.355 | 0.8325 | Yes | ||
| 24 | 5427 | "POLE2 (polymerase (DNA directed), epsilon 2 (p59 subunit))" | 2176 | 17.332 | 0.8378 | Yes | ||
| 25 | 5984 | "RFC4 (replication factor C (activator 1) 4, 37kDa)" | 2335 | 15.735 | 0.8405 | Yes | ||
| 26 | 5981 | "RFC1 (replication factor C (activator 1) 1, 145kDa)" | 2519 | 14.098 | 0.8408 | Yes | ||
| 27 | 5422 | "POLA1 (polymerase (DNA directed), alpha 1, catalytic subunit)" | 2543 | 13.945 | 0.8490 | Yes | ||
| 28 | 6117 | "RPA1 (replication protein A1, 70kDa)" | 2549 | 13.888 | 0.8580 | Yes | ||
| 29 | 10714 | "POLD3 (polymerase (DNA-directed), delta 3, accessory subunit)" | 3097 | 10.449 | 0.8380 | No | ||
| 30 | 79621 | "RNASEH2B (ribonuclease H2, subunit B)" | 4592 | 5.003 | 0.7677 | No | ||
| 31 | 5426 | "POLE (polymerase (DNA directed), epsilon)" | 5878 | 2.520 | 0.7060 | No | ||
| 32 | 1763 | DNA2 (DNA replication helicase 2 homolog (yeast)) | 6049 | 2.310 | 0.6992 | No | ||
| 33 | 29935 | "RPA4 (replication protein A4, 34kDa)" | 8120 | 0.684 | 0.5976 | No | ||
| 34 | 3978 | "LIG1 (ligase I, DNA, ATP-dependent)" | 10691 | -0.024 | 0.4710 | No | ||
| 35 | 84153 | "RNASEH2C (ribonuclease H2, subunit C)" | 14425 | -1.195 | 0.2878 | No | ||
| 36 | 57804 | "POLD4 (polymerase (DNA-directed), delta 4)" | 17078 | -4.447 | 0.1600 | No |
